TAK1–TAB2 Signaling Contributes to Bone Destruction by Breast Carcinoma Cells
نویسندگان
چکیده
منابع مشابه
TAK1-TAB2 signaling contributes to bone destruction by breast carcinoma cells.
Advanced-stage breast cancers frequently metastasize to the bones and cause bone destruction, but the underlying mechanism is not fully understood. This study presents evidence that TGF-β-activated protein kinase 1 (TAK1) signaling in tumor cells promotes bone destruction by metastatic breast carcinoma cells, controlling expression of prometastatic factors including matrix metalloproteinase (MM...
متن کاملAngiogenesis, Metastasis, and the Cellular Microenvironment TAK1–TAB2 Signaling Contributes to Bone Destruction by Breast Carcinoma Cells
Advanced-stage breast cancers frequently metastasize to the bones and cause bone destruction, but the underlying mechanism is not fully understood. This study presents evidence that TGF-b–activated protein kinase 1 (TAK1) signaling in tumor cells promotes bone destruction by metastatic breast carcinoma cells, controlling expression of prometastatic factors including matrix metalloproteinase (MM...
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ژورنال
عنوان ژورنال: Molecular Cancer Research
سال: 2011
ISSN: 1541-7786,1557-3125
DOI: 10.1158/1541-7786.mcr-10-0196